bergamottin, 7380-40-7

Articles:

PubMed:	Bergamottin, a natural furanocoumarin obtained from grapefruit juice induces chemosensitization and apoptosis through the inhibition of STAT3 signaling pathway in tumor cells.
PubMed:	Absence of Furanocoumarins in Advantra Z® (Citrus aurantium, Bitter Orange) Extracts.
PubMed:	Labeled content of two furanocoumarins in dietary supplements correlates with neither actual content nor CYP3A inhibitory activity.
PubMed:	Components of foods inhibit a drug exporter, human multidrug and toxin extrusion transporter 1.
PubMed:	Thorough investigation of the oxygen heterocyclic fraction of lime (Citrus aurantifolia (Christm.) Swingle) juice.
PubMed:	Comprehensive profiling and marker identification in non-volatile citrus oil residues by mass spectrometry and nuclear magnetic resonance.
PubMed:	Selective oxidation reactions of natural compounds with hydrogen peroxide mediated by methyltrioxorhenium.
PubMed:	Rapid Quantitation of Furanocoumarins and Flavonoids in Grapefruit Juice using Ultra-Performance Liquid Chromatography.
PubMed:	Protein sequestration of lipophilic furanocoumarins in grapefruit juice.
PubMed:	In vitro inhibition of cytochrome P450 3A4 by Aronia melanocarpa constituents.
PubMed:	Chemical composition of hexane extract of Citrus aurantifolia and anti-Mycobacterium tuberculosis activity of some of its constituents.
PubMed:	Grapefruit (Citrus paradisi Macfad) phytochemicals composition is modulated by household processing techniques.
PubMed:	Degreening and postharvest storage influences 'Star Ruby' grapefruit (Citrus paradisi Macf.) bioactive compounds.
PubMed:	Bergamottin is a competitive inhibitor of CYP1A1 and is antimutagenic in the Ames test.
PubMed:	Effect of maturity, processing, and storage on the furanocoumarin composition of grapefruit and grapefruit juice.
PubMed:	Identification of the residue in human CYP3A4 that is covalently modified by bergamottin and the reactive intermediate that contributes to the grapefruit juice effect.
PubMed:	Structure-activity relationships for naturally occurring coumarins as β-secretase inhibitor.
PubMed:	Major furocoumarins in grapefruit juice II: phototoxicity, photogenotoxicity, and inhibitory potency vs. cytochrome P450 3A4 activity.
PubMed:	Major furocoumarins in grapefruit juice I: levels and urinary metabolite(s).
PubMed:	Construction of a model to estimate the CYP3A inhibitory effect of grapefruit juice.
PubMed:	The interaction potential of herbal medicinal products: a luminescence-based screening platform assessing effects on cytochrome P450 and its use with devil's claw (Harpagophyti radix) preparations.
PubMed:	Food-drug interactions: grapefruit juice.
PubMed:	[Furanocoumarins contents and cytochrome P450 3A (CYP3A) inhibitory activities of various processed fruit peel products: outflow of 6',7'-Dihydroxybergamottin during processing treatment of peel].
PubMed:	[Flavonoids--bioactive compounds in fruits juice].
PubMed:	A quantitative high-throughput 96-well plate fluorescence assay for mechanism-based inactivators of cytochromes P450 exemplified using CYP2B6.
PubMed:	Suppression of phorbol-12-myristate-13-acetate-induced tumor cell invasion by bergamottin via the inhibition of protein kinase Cdelta/p38 mitogen-activated protein kinase and JNK/nuclear factor-kappaB-dependent matrix metalloproteinase-9 expression.
PubMed:	Application of the concept of relative photomutagenic potencies to selected furocoumarins in V79 cells.
PubMed:	Minor furanocoumarins and coumarins in grapefruit peel oil as inhibitors of human cytochrome P450 3A4.
PubMed:	Dose-response relationship for the pharmacokinetic interaction of grapefruit juice with dextromethorphan investigated by human urinary metabolite profiles.
PubMed:	Development of a reversed-phase high-performance liquid chromatographic method for analyzing furanocoumarin components in citrus fruit juices and Chinese herbal medicines.
PubMed:	[Studies on chemical constituents in roots and rhizomes of Notopterygium incisum].
PubMed:	In vitro interactions with repeated grapefruit juice administration--to peel or not to peel?
PubMed:	Removal of furanocoumarins in grapefruit juice by edible fungi.
PubMed:	Influence of electron-beam irradiation on bioactive compounds in grapefruits ( Citrus paradisi Macf.).
PubMed:	Evaluation of flavonoids and furanocoumarins from Citrus bergamia (Bergamot) juice and identification of new compounds.
PubMed:	Suppressive Effects of Selected Food Phytochemicals on CD74 Expression in NCI-N87 Gastric Carcinoma Cells.
PubMed:	[Contents of furanocoumarins in grapefruit juice and health foods].
PubMed:	White and colored grapefruit juice produce similar pharmacokinetic interactions.
PubMed:	Effects of naturally occurring coumarins on hepatic drug-metabolizing enzymes in mice.
PubMed:	Effect of grapefruit juice, naringin, naringenin, and bergamottin on the intestinal carrier-mediated transport of talinolol in rats.
PubMed:	Comparative evaluation of 12 immature citrus fruit extracts for the inhibition of cytochrome P450 isoform activities.
PubMed:	Determination of bergamottin in human plasma after grapefruit juice ingestion by an UPLC/MS/MS method.
PubMed:	Aspergillus niger metabolism of citrus furanocoumarin inhibitors of human cytochrome P450 3A4.
PubMed:	Potent inhibition of human cytochrome P450 3A4, 2D6, and 2C9 isoenzymes by grapefruit juice and its furocoumarins.
PubMed:	Distribution of flavonoids and furocoumarins in juices from cultivars of Citrus bergamia Risso.
PubMed:	Grapefruit juice-drug interactions: Grapefruit juice and its components inhibit P-glycoprotein (ABCB1) mediated transport of talinolol in Caco-2 cells.
PubMed:	Esterase inhibition by grapefruit juice flavonoids leading to a new drug interaction.
PubMed:	Polymethoxylated flavones and other phenolic derivates from citrus in their inhibitory effects on P-glycoprotein-mediated transport of talinolol in Caco-2 cells.
PubMed:	The use of heat treatment to eliminate drug interactions due to grapefruit juice.
PubMed:	Impact of citrus soft drinks relative to grapefruit juice on ciclosporin disposition.
PubMed:	Metabolism of bergamottin by cytochromes P450 2B6 and 3A5.
PubMed:	UV-irradiated grapefruit juice loses pharmacokinetic interaction with nifedipine in rats.
PubMed:	Design, synthesis and evaluation of furanocoumarin monomers as inhibitors of CYP3A4.
PubMed:	Synthesis of 8-geranyloxypsoralen analogues and their evaluation as inhibitors of CYP3A4.
PubMed:	Variation of flavonoids and furanocoumarins in grapefruit juices: a potential source of variability in grapefruit juice-drug interaction studies.
PubMed:	Furocoumarins from grapefruit juice and their effect on human CYP 3A4 and CYP 1B1 isoenzymes.
PubMed:	[Effects of sweetie juice on nifedipine pharmacokinetics in rats].
PubMed:	[Comprehensive determination of furanocoumarin derivatives in citrus juice by high performance liquid chromatography].
PubMed:	Distribution of furanocoumarins in grapefruit juice fractions.
PubMed:	Coumarins are competitive inhibitors of cytochrome P450 1B1, with equal potency for allelic variants.
PubMed:	Automated screening with confirmation of mechanism-based inactivation of CYP3A4, CYP2C9, CYP2C19, CYP2D6, and CYP1A2 in pooled human liver microsomes.
PubMed:	Probable interaction of bergamottin and cyclosporine in a lung transplant recipient.
PubMed:	The naturally occurring cytochrome P450 (P450) 2B6 K262R mutant of P450 2B6 exhibits alterations in substrate metabolism and inactivation.
PubMed:	Mechanism-based inhibition of cytochrome P450 3A4 by therapeutic drugs.
PubMed:	Photodynamic and photo-cross-linking potential of bergamottin.
PubMed:	Natural furocoumarins as inducers and inhibitors of cytochrome P450 1A1 in rat hepatocytes.
PubMed:	The grapefruit juice effect is not limited to cytochrome P450 (P450) 3A4: evidence for bergamottin-dependent inactivation, heme destruction, and covalent binding to protein in P450s 2B6 and 3A5.
PubMed:	Bergamottin contribution to the grapefruit juice-felodipine interaction and disposition in humans.
PubMed:	Therapeutic drugs that behave as mechanism-based inhibitors of cytochrome P450 3A4.
PubMed:	Effects of grapefruit juice and orange juice components on P-glycoprotein- and MRP2-mediated drug efflux.
PubMed:	Utility of microtiter plate assays for human cytochrome P450 inhibition studies in drug discovery: application of simple method for detecting quasi-irreversible and irreversible inhibitors.
PubMed:	Two major grapefruit juice components differ in time to onset of intestinal CYP3A4 inhibition.
PubMed:	Inhibition of in-vitro simvastatin metabolism in rat liver microsomes by bergamottin, a component of grapefruit juice.
PubMed:	Two major grapefruit juice components differ in intestinal CYP3A4 inhibition kinetic and binding properties.
PubMed:	Screening of furanocoumarin derivatives in citrus fruits by enzyme-linked immunosorbent assay.
PubMed:	Herbal modulation of P-glycoprotein.
PubMed:	CYP450 dietary inhibitors attenuate TNF-alpha-stimulated endothelial molecule expression and leukocyte adhesion.
PubMed:	Herbal bioactivation: the good, the bad and the ugly.
PubMed:	The effects of fruit juices on drug disposition: a new model for drug interactions.
PubMed:	Time course of recovery of cytochrome p450 3A function after single doses of grapefruit juice.
PubMed:	Bergamottin, lime juice, and red wine as inhibitors of cytochrome P450 3A4 activity: comparison with grapefruit juice.
PubMed:	Naturally occurring coumarins inhibit human cytochromes P450 and block benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene DNA adduct formation in MCF-7 cells.
PubMed:	[Grapefruit juice and drugs: a hazardous combination?].
PubMed:	In vitro inhibition of simvastatin metabolism, a HMG-CoA reductase inhibitor in human and rat liver by bergamottin, a component of grapefruit juice.
PubMed:	Effects of bergamottin on human and monkey drug-metabolizing enzymes in primary cultured hepatocytes.
PubMed:	Earl Grey tea intoxication.
PubMed:	Role of cytochrome P450 1a1 and 1b1 in the metabolic activation of 7,12-dimethylbenz[a]anthracene and the effects of naturally occurring furanocoumarins on skin tumor initiation.
PubMed:	The effect of bergamottin on diazepam plasma levels and P450 enzymes in beagle dogs.
PubMed:	Inhibition of P-glycoprotein transport function by grapefruit juice psoralen.
PubMed:	Effects of furanocoumarin derivatives in grapefruit juice on nifedipine pharmacokinetics in rats.
PubMed:	Seville orange juice-felodipine interaction: comparison with dilute grapefruit juice and involvement of furocoumarins.
PubMed:	Grapefruit-felodipine interaction: effect of unprocessed fruit and probable active ingredients.
PubMed:	Inhibition of P-glycoprotein by orange juice components, polymethoxyflavones in adriamycin-resistant human myelogenous leukemia (K562/ADM) cells.
PubMed:	Effect of furanocoumarin derivatives in grapefruit juice on the uptake of vinblastine by Caco-2 cells and on the activity of cytochrome P450 3A4.
PubMed:	Inhibition selectivity of grapefruit juice components on human cytochromes P450.
PubMed:	Identification of coumarins from lemon fruit (Citrus limon) as inhibitors of in vitro tumor promotion and superoxide and nitric oxide generation.
PubMed:	Isolation of furocoumarins from bergamot fruits as HL-60 differentiation-inducing compounds.
PubMed:	Inhibition of the CYP3A4-mediated metabolism and P-glycoprotein-mediated transport of the HIV-1 protease inhibitor saquinavir by grapefruit juice components.
PubMed:	Identification of coumarins from the fruit of Citrus hystrix DC as inhibitors of nitric oxide generation in mouse macrophage RAW 264.7 cells.
PubMed:	Inactivation of cytochrome P450 3A4 by bergamottin, a component of grapefruit juice.
PubMed:	Effect of naturally occurring coumarins on the formation of epidermal DNA adducts and skin tumors induced by benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene in SENCAR mice.
PubMed:	Inhibitory effects of naturally occurring coumarins on the metabolic activation of benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene in cultured mouse keratinocytes.
PubMed:	[Chemical constituents of Notopterygium incisum Ting].
PubMed:	Effects of a new psoralen, 5-geranoxypsoralen, plus UVA radiation on murine ATPase positive Langerhans cells.
PubMed:	Inhibition and inactivation of murine hepatic ethoxy- and pentoxyresorufin O-dealkylase by naturally occurring coumarins.
PubMed:	Psoralens cleave pBR322 DNA under ultraviolet radiation.
PubMed:	The photobiological activity of 5-geranoxypsoralen and its photoproducts.
PubMed:	Photoreactivity of 5-geranoxypsoralen and lack of photoreaction with DNA.
PubMed:	In vitro photostability and photosensitizing properties of bergamot oil. Effects of a cinnamate sunscreen.