ubiquinol-10
2-(2trans-3,7-dimethyl-2,6-octadienyl)-5,6-dimethoxy-3-methyl-1,4-benzene diol
 
Notes:
Ubiquinol-10 is a benzoquinol and is the reduced product of ubiquinone also called coenzyme Q10.The reduction of ubiquinone to ubiquinol occurs in Complexes I&II in the electron transfer chain. The Q cycle is a process that occurs in cytochrome b[, a component of Complex III in the electron transport chain,and that converts ubiquinol to ubiquinone in a cyclic fashion. When ubiquinol binds to cytochrome b, the pKa of the phenolic group decreases so that the proton ionizes and the phenoxide anion is formed (from wiki) Ubiquinol-10, the reduced form of ubiquinone-10, efficiently scavenges free radicals generated chemically within liposomal membranes. Ubiquinol-10 is about as effective in preventing peroxidative damage to lipids as alpha-tocopherol, which is considered the best lipid-soluble antioxidant in humans. The number of radicals scavenged by each molecule of ubiquinol-10 is 1.1 under certain experimental conditions. In contrast to alpha-tocopherol, ubiquinol-10 is not recycled by ascorbate. However, it is known that ubiquinol-10 can be recycled by electron transport carriers present in various biomembranes and possibly by some enzymes. It is shown that ubiquinol-10 spares alpha-tocopherol when both antioxidants are present in the same liposomal membranes and that ubiquinol-10, like alpha-tocopherol, does not interact with reduced glutathione.It is suggested that ubiquinol-10 is an important physiological lipid-soluble antioxidant. [PMID: 2352956] [HMDB]
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CAS Number: 5677-55-4Picture of molecule3D/inchi
Nikkaji Web: J961.012J
XlogP3-AA: 5.30 (est)
Molecular Weight: 320.42896000
Formula: C19 H28 O4
NMR Predictor: Predict (works with chrome or firefox)
Category: information only not used for fragrances or flavors
 
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Soluble in:
 water, 0.2451 mg/L @ 25 °C (est)
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
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GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
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Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: information only not used for fragrances or flavors
Recommendation for ubiquinol-10 usage levels up to:
 not for fragrance use.
 
Recommendation for ubiquinol-10 flavor usage levels up to:
 not for flavor use.
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EPI System: View
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EPA ACToR: Toxicology Data
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Laboratory Chemical Safety Summary : 5280344
National Institute of Allergy and Infectious Diseases: Data
 2-[(2E)-3,7-dimethylocta-2,6-dienyl]-5,6-dimethoxy-3-methylbenzene-1,4-diol
Chemidplus: 0005677554
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References:
 2-[(2E)-3,7-dimethylocta-2,6-dienyl]-5,6-dimethoxy-3-methylbenzene-1,4-diol
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 5280344
Pubchem (sid): 135073355
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEMBL: View
KEGG (GenomeNet): C00390
HMDB (The Human Metabolome Database): HMDB13111
FooDB: FDB029288
ChemSpider: View
Wikipedia: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
1,4-benzenediol, 2-(3,7-dimethyl-2,6-octadienyl)-5,6-dimethoxy-3-methyl-, (E)-
1,4-benzenediol, 2-[(2E)-3,7-dimethyl-2,6-octadien-1-yl]-5,6-dimethoxy-3-methyl-
 coenzymes QH2
2-((2E)-3,7-dimethyl-2,6-octadienyl)-5,6-dimethoxy-3-methyl-1,4-benzene diol
2-(2trans-3,7-dimethyl-2,6-octadienyl)-5,6-dimethoxy-3-methyl-1,4-benzene diol
2-[(2E)-3,7-dimethylocta-2,6-dienyl]-5,6-dimethoxy-3-methylbenzene-1,4-diol
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Articles:
PubMed: Seasonal and ontogenetic changes modulate oxygen consumption and antioxidant defenses in the cutlassfish Trichiurus lepturus (Pisces, Trichiuridae).
PubMed: Low-Molecular-Weight Hydrophilic and Lipophilic Antioxidants in Nonmelanoma Skin Carcinomas and Adjacent Normal-Looking Skin.
PubMed: The Inhibitory Effects of Anti-Oxidants on Ultraviolet-Induced Up-Regulation of the Wrinkling-Inducing Enzyme Neutral Endopeptidase in Human Fibroblasts.
PubMed: Kinetic Study of Aroxyl-Radical-Scavenging and α-Tocopherol-Regeneration Rates of Five Catecholamines in Solution: Synergistic Effect of α-Tocopherol and Catecholamines.
PubMed: Impact of Antioxidants on Cardiolipin Oxidation in Liposomes: Why Mitochondrial Cardiolipin Serves as an Apoptotic Signal?
PubMed: Disruption of the human COQ5-containing protein complex is associated with diminished coenzyme Q10 levels under two different conditions of mitochondrial energy deficiency.
PubMed: Ubiquinol-10 supplementation improves autonomic nervous function and cognitive function in chronic fatigue syndrome.
PubMed: An Improvement of Oxidative Stress in Diabetic Rats by Ubiquinone-10 and Ubiquinol-10 and Bioavailability after Short- and Long-Term Coenzyme Q10 Supplementation.
PubMed: Both idebenone and idebenol are localized near the lipid-water interface of the membrane and increase its fluidity.
PubMed: Enzymatic process of rice bran: a stabilized functional food with nutraceuticals and nutrients.
PubMed: Stability of ubiquinol-10 (reduced form of coenzyme Q10 ) in human blood.
PubMed: Determination of the coenzyme Q10 status in a large Caucasian study population.
PubMed: Rapid and sensitive analysis of reduced and oxidized coenzyme Q10 in human plasma by ultra performance liquid chromatography-tandem mass spectrometry and application to studies in healthy human subjects.
PubMed: Randomized, double-blind, placebo-controlled pilot trial of reduced coenzyme Q10 for Parkinson's disease.
PubMed: Application of coenzyme Q10 for accelerating soft tissue wound healing after tooth extraction in rats.
PubMed: A comparative study into alterations of coenzyme Q redox status in ageing pigs, mice, and worms.
PubMed: Ubiquinol-10 ameliorates mitochondrial encephalopathy associated with CoQ deficiency.
PubMed: Antioxidants supplementation in elderly cardiovascular patients.
PubMed: Plasma coenzyme Q10 levels in type 2 diabetic patients with retinopathy.
PubMed: Kinetic study of aroxyl radical scavenging and α-tocopheroxyl regeneration rates of pyrroloquinolinequinol (PQQH2, a reduced form of pyrroloquinolinequinone) in dimethyl sulfoxide solution: finding of synergistic effect on the reaction rate due to the coexistence of α-tocopherol and PQQH2.
PubMed: Herbal antioxidant in clinical practice: a review.
PubMed: Ubiquinol-10 supplementation activates mitochondria functions to decelerate senescence in senescence-accelerated mice.
PubMed: Oxidative stress is involved in fatigue induced by overnight deskwork as assessed by increase in plasma tocopherylhydroqinone and hydroxycholesterol.
PubMed: A mouse model of familial ALS has increased CNS levels of endogenous ubiquinol9/10 and does not benefit from exogenous administration of ubiquinol10.
PubMed: Effect of ubiquinol-10 on citral stability and off-flavor formation in oil-in-water (O/W) nanoemulsions.
PubMed: Aroxyl-radical-scavenging rate increases remarkably under the coexistence of α-tocopherol and ubiquinol-10 (or vitamin C): finding of synergistic effect on the reaction rate.
PubMed: Anti-inflammatory effect of ubiquinol-10 on young and senescent endothelial cells via miR-146a modulation.
PubMed: Increased oxidative stress and coenzyme Q10 deficiency in juvenile fibromyalgia: amelioration of hypercholesterolemia and fatigue by ubiquinol-10 supplementation.
PubMed: Correlations between oxidative DNA damage, oxidative stress and coenzyme Q10 in patients with coronary artery disease.
PubMed: Function of plastochromanol and other biological prenyllipids in the inhibition of lipid peroxidation-A comparative study in model systems.
PubMed: Development of singlet oxygen absorption capacity (SOAC) assay method. 3. Measurements of the SOAC values for phenolic antioxidants.
PubMed: Kinetic study of the α-tocopherol-regeneration reaction of ubiquinol-10 in methanol and acetonitrile solutions: notable effect of the alkali and alkaline earth metal salts on the reaction rates.
PubMed: Measurement of oxidized and reduced coenzyme Q in biological fluids, cells, and tissues: an HPLC-EC method.
PubMed: Redox pioneer: professor Roland Stocker.
PubMed: Kinetic study of the quenching reaction of singlet oxygen by Pyrroloquinolinequinol (PQQH(2), a reduced form of Pyrroloquinolinequinone) in micellar solution.
PubMed: Surface lipids as multifunctional mediators of skin responses to environmental stimuli.
PubMed: Ubiquinol-10 and ubiquinone-10 levels in umbilical cord blood of healthy foetuses and the venous blood of their mothers.
PubMed: Coenzyme Q10 treatment ameliorates acute cisplatin nephrotoxicity in mice.
PubMed: Coenzyme Q10 in human blood: native levels and determinants of oxidation during processing and storage.
PubMed: Antioxidant Effects of Lycopene and Ubiquinol-10 on the Oxidative Stress in Rat Hepatocytes Induced by Tert-Buthyl Hydroperoxide.
PubMed: A study of cytochrome bo3 in a tethered bilayer lipid membrane.
PubMed: Increase in the oxidized/total coenzyme Q-10 ratio in the cerebrospinal fluid of Alzheimer's disease patients.
PubMed: Nanoliposomes mediate coenzyme Q10 transport and accumulation across human intestinal Caco-2 cell monolayer.
PubMed: Impedance spectroscopy of bacterial membranes: coenzyme-Q diffusion in a finite diffusion layer.
PubMed: Effects of ubiquinol-10 on microRNA-146a expression in vitro and in vivo.
PubMed: In Vitro Effects of the Reduced Form of Coenzyme Q(10) on Secretion Levels of TNF-alpha and Chemokines in Response to LPS in the Human Monocytic Cell Line THP-1.
PubMed: Comparison between the free-radical-scavenging activities with vitamin E and ubiquinol in biological systems based on their reaction rates: a research account.
PubMed: Characterization of cytochrome bo3 activity in a native-like surface-tethered membrane.
PubMed: High-sensitivity simultaneous analysis of ubiquinol-10 and ubiquinone-10 in human plasma.
PubMed: Redox state of coenzyme Q10 determines its membrane localization.
PubMed: Validation and application of an HPLC-EC method for analysis of coenzyme Q10 in blood platelets.
PubMed: Environmental contaminants and redox status of coenzyme Q10 and vitamin E in Inuit from Nunavik.
PubMed: Protective effects of coenzyme q(10) on decreased oxidative stress resistance induced by simvastatin.
PubMed: Fluorescence studies of the interactions of ubiquinol-10 with liposomes.
PubMed: Kinetic study of the tocopherol regeneration reaction by biological hydroquinones in micellar solution.
PubMed: Kinetics of hypobromous acid-mediated oxidation of lipid components and antioxidants.
PubMed: Coenzyme Q10 (ubiquinol-10) supplementation improves oxidative imbalance in children with trisomy 21.
PubMed: Determination of the ubiquinol-10 and ubiquinone-10 (coenzyme Q10) in human serum by liquid chromatography tandem mass spectrometry to evaluate the oxidative stress.
PubMed: Determination of ubidecarenone (coenzyme Q10, ubiquinol-10) in raw materials and dietary supplements by high-performance liquid chromatography with ultraviolet detection: single-laboratory validation.
PubMed: Bioenergetic and antioxidant properties of coenzyme Q10: recent developments.
PubMed: Fluorescence lifetimes study of alpha-tocopherol and biological prenylquinols in organic solvents and model membranes.
PubMed: Mechanism of quinol oxidation by ferricenium produced by light excitation in reaction centers of photosynthetic bacteria.
PubMed: Ubiquinol-10/lipids ratios in consecutive patients with different angiographic findings.
PubMed: Structure-activity relationship of the free-radical-scavenging reaction by vitamin E (alpha-, beta-, gamma-, delta-Tocopherols) and ubiquinol-10: pH dependence of the reaction rates.
PubMed: Effects of fenofibrate therapy on plasma ubiquinol-10 and ubiquinone-10 levels in Japanese patients with hyperlipidemia and type 2 diabetes mellitus.
PubMed: Daily profile of plasma %CoQ10 level, a biomarker of oxidative stress, in patients with diabetes manifesting postprandial hyperglycaemia.
PubMed: Kinetic study of the quenching reaction of singlet oxygen by tea catechins in ethanol solution.
PubMed: Acute prolonged exercise reduces moderately oxidized LDL in healthy men.
PubMed: Interactions between mitochondrial lipid oxidation and oxymyoglobin oxidation and the effects of vitamin E.
PubMed: Reduction of serum ubiquinol-10 and ubiquinone-10 levels by atorvastatin in hypercholesterolemic patients.
PubMed: Ubiquinol: a potential biomarker for tissue energy requirements and oxidative stress.
PubMed: Investigation of ubiquinol formation in isolated photosynthetic reaction centers by rapid-scan Fourier transform IR spectroscopy.
PubMed: Muscle coenzyme Q: a potential test for mitochondrial activity and redox status.
PubMed: The regular supplementation with an antioxidant mixture decreases oxidative stress in healthy humans. Gender effect.
PubMed: Pro-oxidative effect of alpha-tocopherol in the oxidation of LDL isolated from co-antioxidant-depleted non-diabetic hemodialysis patients.
PubMed: Active oxygen chemistry within the liposomal bilayer. Part III: Locating Vitamin E, ubiquinol and ubiquinone and their derivatives in the lipid bilayer.
PubMed: Synergistic inhibition of lipid peroxidation by vitamin E and a dopamine agonist, cabergoline.
PubMed: Role of beta2-glycoprotein I, LDL-, and antioxidant levels in hypercholesterolemic elderly subjects.
PubMed: Short-term and long-term vitamin C supplementation in humans dose-dependently increases the resistance of plasma to ex vivo lipid peroxidation.
PubMed: Plasma and CSF markers of oxidative stress are increased in Parkinson's disease and influenced by antiparkinsonian medication.
PubMed: Coenzyme Q(10) supplementation inhibits aortic lipid oxidation but fails to attenuate intimal thickening in balloon-injured New Zealand white rabbits.
PubMed: Plasma coenzyme Q10 reference intervals, but not redox status, are affected by gender and race in self-reported healthy adults.
PubMed: Hypochlorous acid-mediated oxidation of lipid components and antioxidants present in low-density lipoproteins: absolute rate constants, product analysis, and computational modeling.
PubMed: Anisotropy measurements of intrinsic fluorescence of prenyllipids reveal much higher mobility of plastoquinol than alpha-tocopherol in model membranes.
PubMed: [Determination of coenzyme Q and alpha-tocopherol in mouse plasma and tissue mitochondria by liquid chromatography with electrochemical detection].
PubMed: The mammalian cytosolic selenoenzyme thioredoxin reductase reduces ubiquinone. A novel mechanism for defense against oxidative stress.
PubMed: Higher oxidation and lower antioxidant levels in peripheral blood plasma and bone marrow plasma from advanced cancer patients.
PubMed: Plasma antioxidants in pediatric patients with glycogen storage disease, diabetes mellitus, and hypercholesterolemia.
PubMed: Coenzyme Q10 and differences in coronary heart disease risk in Asian Indians and Chinese.
PubMed: Effects of diet and simvastatin on serum lipids, insulin, and antioxidants in hypercholesterolemic men: a randomized controlled trial.
PubMed: Role of active oxygen species and antioxidants in photoaging.
PubMed: Coenzyme Q blocks biochemical but not receptor-mediated apoptosis by increasing mitochondrial antioxidant protection.
PubMed: Neutral magnesium-dependent sphingomyelinase from liver plasma membrane: purification and inhibition by ubiquinol.
PubMed: Beneficial effects of alpha-lipoic acid and ascorbic acid on endothelium-dependent, nitric oxide-mediated vasodilation in diabetic patients: relation to parameters of oxidative stress.
PubMed: Effects of diets enriched with two different plant stanol ester mixtures on plasma ubiquinol-10 and fat-soluble antioxidant concentrations.
PubMed: Dietary cosupplementation with vitamin E and coenzyme Q(10) inhibits atherosclerosis in apolipoprotein E gene knockout mice.
PubMed: Plasma vitamin C levels are decreased and correlated with brain damage in patients with intracranial hemorrhage or head trauma.
PubMed: Enhanced oxidative susceptibility and reduced antioxidant content of metabolic precursors of small, dense low-density lipoproteins.
PubMed: Anti-atherogenic effect of coenzyme Q10 in apolipoprotein E gene knockout mice.
PubMed: Content of liver and brain ubiquinol-9 and ubiquinol-10 after chronic ethanol intake in rats subjected to two levels of dietary alpha-tocopherol.
PubMed: Simultaneous detection of ubiquinol-10, ubiquinone-10, and tocopherols in human plasma microsamples and macrosamples as a marker of oxidative damage in neonates and infants.
PubMed: DISTRIBUTION OF LIPID-SOLUBLE ANTIOXIDANTS IN LIPOPROTEINS FROM HEALTHY SUBJECTS. I. CORRELATION WITH PLASMA ANTIOXIDANT LEVELS AND COMPOSITION OF LIPOPROTEINS.
PubMed: Decreased serum ubiquinol-10 levels in healthy subjects during exercise at maximal oxygen uptake.
PubMed: Polyenylphosphatidylcholine protects against alcohol but not iron-induced oxidative stress in the liver.
PubMed: Distribution of lipid-soluble antioxidants in lipoproteins from healthy subjects. I. Correlation with plasma antioxidant levels and composition of lipoproteins.
PubMed: Coenzyme Q10 enrichment decreases oxidative DNA damage in human lymphocytes.
PubMed: Dose-dependent increase of oxidative damage in the testes of rats subjected to acute iron overload.
PubMed: Higher levels of antioxidant defenses in enalapril-treated versus non-enalapril-treated hemodialysis patients.
PubMed: Comparative study on dynamics of antioxidative action of alpha-tocopheryl hydroquinone, ubiquinol, and alpha-tocopherol against lipid peroxidation.
PubMed: Lead intoxication: antioxidant defenses and oxidative damage in rat brain.
PubMed: Oxidative stress in testes of rats subjected to chronic iron intoxication and alpha-tocopherol supplementation.
PubMed: Plasma ubiquinone to ubiquinol ratio in patients with hepatitis, cirrhosis, and hepatoma, and in patients treated with percutaneous transluminal coronary reperfusion.
PubMed: Plasma ubiquinol-10 as a marker for disease: is the assay worthwhile?
PubMed: A role for reduced coenzyme Q in atherosclerosis?
PubMed: Lipophilic antioxidants in blood plasma as markers of atherosclerosis: the role of alpha-carotene and gamma-tocopherol.
PubMed: Closed head injury in the rat induces whole body oxidative stress: overall reducing antioxidant profile.
PubMed: Automated high-performance liquid chromatographic method with precolumn reduction for the determination of ubiquinol and ubiquinone in human plasma.
PubMed: Is ascorbic acid an antioxidant for the plasma membrane?
PubMed: Alcohol-induced pancreatic oxidative stress: protection by phospholipid repletion.
PubMed: The interaction of coenzyme Q with phosphatidylethanolamine membranes.
PubMed: Oxidative stress in newborn infants with and without asphyxia as measured by plasma antioxidants and free fatty acids.
PubMed: High-performance liquid chromatography-coulometric electrochemical detection of ubiquinol 10, ubiquinone 10, carotenoids, and tocopherols in neonatal plasma.
PubMed: Vitamin E enhances Ca(2+)-mediated vulnerability of immature cerebellar granule cells to ischemia.
PubMed: Making vitamin C lipophilic enhances its protective effect against free radical induced peroxidation of low density lipoprotein.
PubMed: Antioxidant content in low density lipoprotein and lipoprotein oxidation in vivo and in vitro.
PubMed: Oxidative stress in patients with hepatitis, cirrhosis, and hepatoma evaluated by plasma antioxidants.
PubMed: Oxidation and antioxidation of human low-density lipoprotein and plasma exposed to 3-morpholinosydnonimine and reagent peroxynitrite.
PubMed: Kinetics of electron and proton transfer to ubiquinone-10 and from ubiquinol-10 in a self-assembled phosphatidylcholine monolayer.
PubMed: Oxidation of high density lipoproteins. I. Formation of methionine sulfoxide in apolipoproteins AI and AII is an early event that accompanies lipid peroxidation and can be enhanced by alpha-tocopherol.
PubMed: How different constituents of human plasma and low density lipoprotein determine plasma oxidizability by copper.
PubMed: Oxidation of free fatty acids in low density lipoprotein by 15-lipoxygenase stimulates nonenzymic, alpha-tocopherol-mediated peroxidation of cholesteryl esters.
PubMed: Dietary alpha-tocopherol supplementation on antioxidant defenses after in vivo iron overload in rats.
PubMed: Mechanisms of lipid peroxidation in human blood plasma: a kinetic approach.
PubMed: Alpha-tocopheryl hydroquinone is an efficient multifunctional inhibitor of radical-initiated oxidation of low density lipoprotein lipids.
PubMed: Simultaneous detection of ubiquinol and ubiquinone in human plasma as a marker of oxidative stress.
PubMed: Oxidation process of bovine heart ubiquinol-cytochrome c reductase as studied by stopped-flow rapid-scan spectrophotometry and simulations based on the mechanistic Q cycle model.
PubMed: Effect of lipid peroxidation products and antioxidants on the formation of probucol radical in low density lipoproteins.
PubMed: Evaluation of antioxidants, protein, and lipid oxidation products in blood from sporadic amyotrophic lateral sclerosis patients.
PubMed: Plasma ubiquinol-10 is decreased in patients with hyperlipidaemia.
PubMed: Plasma and LDL levels of major lipophilic antioxidants are similar in patients with advanced atherosclerosis and age-matched controls.
PubMed: Increased levels of plasma cholesteryl ester hydroperoxides in patients with subarachnoid hemorrhage.
PubMed: Human meconium has potent antioxidative properties.
PubMed: The protective role of ubiquinol-10 against formation of lipid hydroperoxides in human seminal fluid.
PubMed: Ubiquinol-10 and total peroxyl radical trapping capacity of LDL lipoproteins during aging: the effects of Q-10 supplementation.
PubMed: Oxidation of LDL and their subfractions: kinetic aspects and CoQ10 content.
PubMed: Inhibition of LDL oxidation by ubiquinol-10. A protective mechanism for coenzyme Q in atherogenesis?
PubMed: Plasma ratio of ubiquinol and ubiquinone as a marker of oxidative stress.
PubMed: Mechanisms and dynamics of antioxidant action of ubiquinol.
PubMed: Endogenous and exogenous regulation of redox-properties of coenzyme Q.
PubMed: Whole plasma oxidation assay as a measure of lipoprotein oxidizability.
PubMed: The redox status of coenzyme Q10 in total LDL as an indicator of in vivo oxidative modification. Studies on subjects with familial combined hyperlipidemia.
PubMed: Effects of acute prolonged exercise on-serum and LDL oxidation and antioxidant defences.
PubMed: 3-Hydroxyanthranilic acid is an efficient, cell-derived co-antioxidant for alpha-tocopherol, inhibiting human low density lipoprotein and plasma lipid peroxidation.
PubMed: Fish antioxidant defenses--a comparative approach.
PubMed: Radical-initiated lipid peroxidation in low density lipoproteins: insights obtained from kinetic modeling.
PubMed: Dietary antioxidants in disease prevention.
PubMed: Antioxidant and prooxidant activity of alpha-tocopherol in human plasma and low density lipoprotein.
PubMed: Alpha-tocopherol as a reductant for Cu(II) in human lipoproteins. Triggering role in the initiation of lipoprotein oxidation.
PubMed: Cosupplementation with coenzyme Q prevents the prooxidant effect of alpha-tocopherol and increases the resistance of LDL to transition metal-dependent oxidation initiation.
PubMed: Red wine consumption does not affect oxidizability of low-density lipoproteins in volunteers.
PubMed: How different constituents of low density lipoprotein determine its oxidizability by copper: a correlational approach.
PubMed: Islet cell antibodies in diabetes mellitus associated with a mitochondrial tRNA(Leu(UUR)) gene mutation.
PubMed: Monitoring of ubiquinol-10, ubiquinone-10, carotenoids, and tocopherols in neonatal plasma microsamples using high-performance liquid chromatography with coulometric electrochemical detection.
PubMed: Depleted mucosal antioxidant defences in inflammatory bowel disease.
PubMed: Dietary antioxidants and cigarette smoke-induced biomolecular damage: a complex interaction.
PubMed: Coantioxidants make alpha-tocopherol an efficient antioxidant for low-density lipoprotein.
PubMed: Inverse deuterium kinetic isotope effect for peroxidation in human low-density lipoprotein (LDL): a simple test for tocopherol-mediated peroxidation of LDL lipids.
PubMed: Differing alpha-tocopherol oxidative lability and ascorbic acid sparing effects in buoyant and dense LDL.
PubMed: Human suction blister interstitial fluid prevents metal ion-dependent oxidation of low density lipoprotein by macrophages and in cell-free systems.
PubMed: Antioxidative activity of ubiquinol-10 at physiologic concentrations in human low density lipoprotein.
PubMed: Vitamin C prevents metal ion-dependent initiation and propagation of lipid peroxidation in human low-density lipoprotein.
PubMed: Measurements of in Vivo Ubiquinone Reduction Levels in Plant Cells.
PubMed: Prevention of tocopherol-mediated peroxidation in ubiquinol-10-free human low density lipoprotein.
PubMed: Oxidative damage to lipids and DNA concurrent with decrease of antioxidants in rat testes after acute iron intoxication.
PubMed: Oxidative modifications of blood serum in humans with coronary artery disease.
PubMed: Antioxidant properties of plastoquinol and other biological prenylquinols in liposomes and solution.
PubMed: Radical-mediated oxidation of isolated human very-low-density lipoprotein.
PubMed: Free and albumin-bound bilirubin are efficient co-antioxidants for alpha-tocopherol, inhibiting plasma and low density lipoprotein lipid peroxidation.
PubMed: The effect of iron overload on rat plasma and liver oxidant status in vivo.
PubMed: Low density lipoprotein oxidizability by copper correlates to its initial ubiquinol-10 and polyunsaturated fatty acid content.
PubMed: Formation of non-cyclooxygenase-derived prostanoids (F2-isoprostanes) in plasma and low density lipoprotein exposed to oxidative stress in vitro.
PubMed: Oxidative susceptibility of low density lipoprotein subfractions is related to their ubiquinol-10 and alpha-tocopherol content.
PubMed: Enzymic and non-enzymic antioxidants in epidermis and dermis of human skin.
PubMed: Content of antioxidants, preformed lipid hydroperoxides, and cholesterol as predictors of the susceptibility of human LDL to metal ion-dependent and -independent oxidation.
PubMed: Natural antioxidants and atherosclerosis.
PubMed: The oxidation of blood plasma and low density lipoprotein components by chemically generated singlet oxygen.
PubMed: Extracellular reduction of ubiquinone-1 and -10 by human Hep G2 and blood cells.
PubMed: Decreased plasma ubiquinone-10 concentration in patients with mevalonate kinase deficiency.
PubMed: Kinetic study of free-radical-scavenging action of biological hydroquinones (reduced forms of ubiquinone, vitamin K and tocopherol quinone) in solution.
PubMed: Fluorescence properties of plastoquinol, ubiquinol and alpha-tocopherol quinol in solution and liposome membranes.
PubMed: Circulating lipid hydroperoxide levels in human hyperhomocysteinemia. Relevance to development of arteriosclerosis.
PubMed: Comparative antioxidant activity of tocotrienols and other natural lipid-soluble antioxidants in a homogeneous system, and in rat and human lipoproteins.
PubMed: Oxidation of low-density lipoprotein with hypochlorite causes transformation of the lipoprotein into a high-uptake form for macrophages.
PubMed: Antioxidant protection against hypochlorous acid in human plasma.
PubMed: Autoxidation of lipids and antioxidation by alpha-tocopherol and ubiquinol in homogeneous solution and in aqueous dispersions of lipids: unrecognized consequences of lipid particle size as exemplified by oxidation of human low density lipoprotein.
PubMed: Vitamin E in human low-density lipoprotein. When and how this antioxidant becomes a pro-oxidant.
PubMed: Interaction of nitrogen dioxide with human plasma. Antioxidant depletion and oxidative damage.
PubMed: Stopped-flow kinetic study of vitamin E regeneration reaction with biological hydroquinones (reduced forms of ubiquinone, vitamin K, and tocopherolquinone) in solution.
PubMed: High density lipoprotein is the major carrier of lipid hydroperoxides in human blood plasma from fasting donors.
PubMed: The participation of nitric oxide in cell free- and its restriction of macrophage-mediated oxidation of low-density lipoprotein.
PubMed: Dietary supplementation with coenzyme Q10 results in increased levels of ubiquinol-10 within circulating lipoproteins and increased resistance of human low-density lipoprotein to the initiation of lipid peroxidation.
PubMed: Ascorbic acid protects lipids in human plasma and low-density lipoprotein against oxidative damage.
PubMed: Characterization of a quinole-oxidase activity in crude extracts of Thermoplasma acidophilum and isolation of an 18-kDa cytochrome.
PubMed: Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does alpha-tocopherol.
PubMed: Effect of antioxidants on oxidative modification of LDL.
PubMed: Antioxidant activity of ubiquinol in solution and phosphatidylcholine liposome.
PubMed: Stopped-flow kinetic study of the regeneration reaction of tocopheroxyl radical by reduced ubiquinone-10 in solution.
PubMed: Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations.
PubMed: Oxidative stress and abnormal cholesterol metabolism in patients with adult respiratory distress syndrome.
PubMed: Presence of cholesteryl ester hydroperoxide in human blood plasma.
PubMed: Isolation and partial characterization of a cytochrome-o complex from chromatophores of the photosynthetic bacterium Rhodospirillum rubrum FR1.
PubMed: Human serum ubiquinol-10 levels and relationship to serum lipids.
PubMed: Evaluation of an isoluminol chemiluminescence assay for the detection of hydroperoxides in human blood plasma.
PubMed: Determination of reduced and total ubiquinones in biological materials by liquid chromatography with electrochemical detection.
PubMed: Quantitative determination of vitamin E and oxidized and reduced coenzyme Q by high-performance liquid chromatography with in-line ultraviolet and electrochemical detection.
PubMed: Solvation properties of ubiquinone-10 in solvents of different polarity.
PubMed: Simultaneous determination of tocopherols, ubiquinols, and ubiquinones in blood, plasma, tissue homogenates, and subcellular fractions.
PubMed: Fluorescence probe studies of the interaction of ubiquinone-10 and ubiquinol-10 with phosphatidylcholine bilayers.
PubMed: Simultaneous determination of ubiquinone-10 and ubiquinol-10 in tissues and mitochondria by high performance liquid chromatography.
PubMed: Identification of an endogenous electron donor for biohydrogenation as alpha-tocopherolquinol.
PubMed: Ubiquinones have surface-active properties suited to transport electrons and protons across membranes.
PubMed: STUDIES ON COENZYME Q. THE ISOLATION, CHARACTERIZATION, AND GENERAL PROPERTIES OF A PARTLY REDUCED COENZYME Q10 FROM PENICILLIUM STIPITATUM.
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